Investigating the Role of Gut Microbiota Dysbiosis in the Pathogenesis and Advancement of Alzheimer's Disease: A Comprehensive Multi-Omics Approach

Abstract

Alzheimer's disease (AD) and other neurodegenerative diseases pose significant global health challenges due to their progressive rate and lack of effective therapies Recent research suggests an important role for gut bacteria small play in the incidence and progression of these diseases, but the mechanisms remain elusive , it is comprehensive-sufficient- omics- When the method was applied, the study used pathways used microbial screening methods with 16S rRNA sequencing and metagenomics to screen working water samples from AD patients and healthy controls to identify specific microbial changes and their relationships between them and disease severity There was a decrease in beneficial bacteria and an increase in harmful, inflammatory bacteria such as Escherichia/Shigella. These microbial changes were associated with moderate cognitive impairment, as measured by Mini Mental Status Examination (MMSE) scores. Analysis of the metabolites indicated that these microbial alterations could affect important pathways, including the production of short-chain fatty acids (SCFAs) and immune modulation, a may increase neurodegeneration and neurodegeneration Our contributions include identification of species and metabolites, and exploration of potential therapeutic targets Dysbiotic microbial signatures identified in AD patients and microbial-based interventions, such as probiotics, dietary modifications, and fecal microbial transplantation, have been administered to restore a healthy gut microbiota and reduce some of the symptoms of disease